SBG talked about a contest, but really I just want to BS about expectations. This in no way should replace any contest, but games are starting soon (four teams already have finished games), and we should do this before we know more.
Typical things to venture:
Division Champs: ALC, ALW, ALE, NLC, NLW, NLE
Two wild cards per league (feel free to rank them, I won't)
World Series winner and loser.
Also postseason awards, one each per league:
Most Valuable Players
Cy Young Awardees
Managers of the Year
Rookies of the Year
Comeback Players of the Year
If you feel like making further-out guesses, there are Golden Gloves, Silver Sluggers, All-Star starters, All-Star reserves, and MVPs for each of the following: ASG, ALCS, NLCS, and World Series.
Go at it.