Bob "Death to Flying Things" Ferguson (1845)
Zane Grey (1872)
George Burns (1893)
Pinky Hargrave (1896)
Pedro Cepeda (1906)
Don Hutson (1913)
Jackie Robinson (1919)
Ernie Banks (1931)
Hank Aguirre (1931)
Nolan Ryan (1947)
Fred Kendall (1949)
Ted Power (1955)
Ed Wade (1956)
Francisco Oliveras (1963)
Yuniesky Betancourt (1982)

Better known as an author of western novels, Zane Grey played outfield for two years in the low minors, batting .323 in 86 games.  He also wrote several books about baseball. 

Pedro Cepeda is the father of Orlando Cepeda and is considered by some to have been a better player; he was known as the Babe Ruth of Puerto Rico. 

Don Hutson, a charter member of the Pro Football Hall of Fame, played in the low minors from 1936-1937, hitting .301 in 194 games.

Right-hander Francisco Javier (Noa) Oliveras made his major league debut with the Twins, pitching for them in 1989.  He was born in Santurce, Puerto Rico and signed with Baltimore as a free agent in 1980.  He played his first full season at AA in 1982 at age 19 and did quite well, posting a 3.55 ERA and a 1.21 WHIP.  He struggled after that, however, not posting another ERA below four until 1987, when he again spent most of the season at AA.  He became a minor league free agent after the 1987 season and signed with Minnesota.  Most of his time in the Twins' organization was spent in AAA, but he was in the majors for the months of May and June of 1989.  He pitched about like you'd expect someone with his track record to pitch:  in 12 games, eight of them starts, he went 3-4, 4.53 with a WHIP of 1.42 and an ERA+ of 92.  Oliveras began 1990 with AAA Portland, but was traded to San Francisco at the end of May for a player to be named later, who turned out to be Ed Gustafson.  He played for the Giants most of the rest of 1990, nearly all of 1991, and most of 1992, working primarily as a reliever.  He did a good job for them, posting an ERA in the mid-threes and WHIPs around 1.2.  He became a free agent after the 1992 season and signed with Texas.  Things did not go well for him there:  he failed to make the team, had a poor year in AAA, and was released after the season.  He showed up in 1998, playing for Nashua in the independent Atlantic League, but other than that he was done as an active player.  No information about Francisco Oliveras since then was readily available.